SNS: Special Letter: Decoding DNA: The Other 97%, in Real Time


Volume 17, Issue 19
Week of May 12, 2014
In This Issue
Feature: Special Letter: Decoding DNA: The Other 97%, In Real Time

  • The Historic Standard
  • The Four Bases of DNA
  • “Transcription” and “Translation”: Reading DNA and RNA
  • Epigenetics
  • Genomics, Non-Coding Portions, and Cancer
  • The Influence, and Limitations, of Sanger Sequencing
  • Current Limits
  • A Bacteria-Derived Polymerase: “A Puzzle in Which All Pieces Are Square”
  • The Importance of the Non-Coding Protein Region
  • Enter Exonucleases
  • Adaptation to Direct Sequencing of RNA
  • Looking Beyond the Exome
  • About Edward Arvisais

Publisher’s Note: This week’s issue is an absolute Must Read for anyone interested in the future of genetics, healthcare, biomedicine, and related issues. If you need to understand how DNA works, and – more important from a pragmatic perspective – how our current techniques fail to reveal real DNA sequences, and how to fix the problem, read on. SNS members are aware that we long ago warned about the use of the term “junk” DNA: nature, in its evolutionary cloak, abhors not only a vacuum, but also any waste in energy or structure. This week’s issue will help members understand why all base pairs should be considered to have been conserved for a purpose, and how important it is to read them – and How to read them.We are now leaving the first- and second- generation worlds of genetic decoding, when we all picked the low-hanging fruit and just ignored the rest. Thanks to companies like NorthShore Bio, a company we are proud to have as a FiReStarter Company this year, we are now going to go back, go deeper, and get the real story, the whole story, the complete read of our genetic codes. – mra.

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